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. 2022 Jan 3;41:3. doi: 10.1186/s13046-021-02208-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — The evaluation of clinical importance of miR-23a-3p. A Dendrogram of miRNAs clustered based on a dissimilarity measure (1-TOM) through WGCNA analysis. B Module member count, ME-clinical traits correlation (Pearson) and P-value indicated for each module. C Scatterplots showing the correlations between gene module membership in the blue module and gene significance for cirrhosis. D A dot plot showing the ranking of miRNAs according to their log2 fold change. E Progression-free survival curve of miR-23a-3p in HCC patients treated with sorafenib. Data were gathered from the GSE56059. F Representative images of miR-23a-3p and DAPI staining in the human HCC tissue microarray. G Increased miR-23a-3p expression observed in recurrent HCC, P = 0.0345. H OS and I RFS outcomes based on Kaplan-Meier survival analysis. The increased expression of miR-23a-3p was significantly associated with poor OS and DFS with P-values 0.0190 and 0.0184, respectively. F Multivariate Cox analysis showing the association between clinicopathologic factors and HCC patient survival outcome. The expression of MiR-23a-3p is significant only in RFS. **P < 0.01, *P < 0.05