Table 4.
Ventricular and atrial reference values indexed to BSA for females age 35 to 75 years, stratified by 10-year age categories
| CMR variables | 35 ≤ Age < 45 years (n = 228) |
45 ≤ Age < 55 years (n = 744) |
55 < = Age < 65 years (n = 795) |
65 ≤ Age < 75 years (n = 313) |
|---|---|---|---|---|
| LVEF, % | 64 ± 5 (53–74) | 64 ± 5 (54–75) | 64 ± 6 (53–76) | 65 ± 6 (54–77) |
| LVSV, indexed to BSA (ml/m2) | 45 ± 7 (30–59) | 43 ± 7 (29–57) | 41 ± 7(28–55) | 40 ± 6 (28–52) |
| LVEDV, indexed to BSA (ml/m2) | 70 ± 11 (49–91) | 67 ± 10 (47–88) | 64 ± 10 (44–84) | 62 ± 9 (44–79) |
| LVESV, indexed to BSA (ml/m2) | 25 ± 6 (14–37) | 24 ± 6 (13–35) | 23 ± 6 (11–34) | 21 ± 5 (11–32) |
| LV mass, indexed to BSA (g/m2) | 48 ± 7 (33–62) | 47 ± 8 (32–63) | 48 ± 7 (33–63) | 46 ± 8 (31–62) |
| LV mass to volume ratio (g/ml) | 0.69 ± 0.11 (0.47–0.91) | 0.72 ± 0.12 (0.47–0.96) | 0.76 ± 0.14 (0.50–1.03) | 0.76 ± 0.14 (0.49–1.04) |
| RVEF, % | 56 ± 6 (45–68) | 58 ± 6 (46–69) | 58 ± 7 (45–71) | 59 ± 6 (47–72) |
| RVESV, indexed to BSA (ml/m2) | 44 ± 7 (30–59) | 43 ± 7 (28–57) | 41 ± 7 (27–54) | 39 ± 6 (27–52) |
| RVEDV, indexed to BSA (ml/m2) | 79 ± 13 (53–105) | 74 ± 13 (49–100) | 71 ± 13 (46–96) | 67 ± 11 (46–88) |
| RVESV, indexed to BSA (ml/m2) | 35 ± 8 (18–52) | 32 ± 8 (16–48) | 30 ± 8 (13–47) | 28 ± 7 (14–42) |
| Min. LA volume, indexed to BSA(ml/m2) | 17 ± 5 ( 6–27) | 18 ± 6 (7–29) | 19 ± 6 (7–32) | 21 ± 7 (7–34) |
| Max. LA volume, indexed to BSA(ml/m2) | 34 ± 8 (19–50) | 37 ± 9 (20–54) | 37 ± 9 (19–55) | 38 ± 9 (20–57) |
| LA SV, indexed to BSA(ml/m2) | 52 ± 11 (30–73) | 50 ± 10 (30–71) | 48 ± 11 (26–69) | 47 ± 10 (27–67) |
| LA EF (%) | 18 ± 5 ( 7–28) | 18 ± 6 (7–30) | 18 ± 6 (6–29) | 18 ± 6 (7–29) |
Values are for females (n = 2080, age 35 to 75 years), reported as mean ± SD (normal range), stratified by 10-year categories. Indexed values are normalized to BSA. Normal reference ranges are defined as the 95% prediction interval
Study cohort—excluded subjects with history of CVD or with risk factors of CVD -hypertension, diabetes, obesity, smoking or dyslipidemia
History of CVD—Aortic stenosis, Atrial fibrillation, Heart failure, Mitral stenosis, Previous PCI, Previous CABG, Valve surgery, TAVI, Hx of myocardial infarction
Reference ranges were calculated based on the formulae mean ± t0.975,n−1*sqrt[(n + 1)/n]*SD
LV Left ventricular; RV right ventricular; EF ejection fraction; SV stroke volume; EDV end-diastolic volume; ESV end-systolic volume; LA left atrium; Min minimum; Max maximum
*p value for testing if all the means are equal