Table 4.

Univariate and multivariable Cox regression analysis of prognostic factors for cardiovascular mortality

Characteristic	Cox Univariate		Cox Multivariate
	HR (95% CI)	P–value	HR (95% CI)	P–value	HR (95% CI)	P–value
Galectin–3 (> 8.65 versus ≤8.65 ng/ml)	2.47 (1.25–4.87)	P < 0.01	2.13 (1.07–4.26)	0.03	–	–
Galectin–3 (continuous variable)	1.01 (0.97–1.05)	0.61	–	–	1.01 (0.98–1.05)	0.49
Age (years)	1.06 (1.05–1.08)	P < 0.01	1.05 (1.03–1.07)	P < 0.01	1.05 (1.04–1.07)	P < 0.01
ESRD due to diabetes (yes versus no)	2.66 (1.86–3.80)	P < 0.01	2.52 (1.35–4.72)	P < 0.01	2.43 (1.30–4.53)	P < 0.01
ESRD due to glomerulonephritis (yes versus no)	0.35 (0.23–0.54)	P < 0.01
ESRD due to hypertension (yes versus no)	1.53 (1.02–2.30)	0.04	2.01 (1.04–3.88)	0.04
Albumin (g/l)	0.85 (0.80–0.90)	P < 0.01	0.91 (0.85–0.97)	P < 0.01	0.91 (0.85–0.97)	P < 0.01
Single–pool Kt/V	0.38 (0.18–0.83)	0.01	0.30 (0.12–0.72)	P < 0.01	0.29 (0.12–0.69)	P < 0.01
Alkaline phosphatase (u/l)	1.003 (1.001–1.004)	0.001	1.004 (1.002–1.005)	P < 0.01	1.004 (1.002–1.005)	P < 0.01
Sodium (mmol/l)	0.92 (0.88–0.97)	P < 0.01

Abbreviations: CI confidence interval, ESRD end–stage renal disease, HR hazard ratio