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. Author manuscript; available in PMC: 2022 May 1.
Published in final edited form as: J Mol Cell Cardiol. 2021 Jan 29;154:6–20. doi: 10.1016/j.yjmcc.2021.01.001

Figure 4. Aortic valve regulation of high mannose N-glycoforms.

Figure 4.

A) Example spatial patterns of high mannose structures. Normal aortic valve demonstrates localization to the fibrosa, while AS valves show diffuse expression. Expression extends from the valve to the aorta in AA 2 weeks, appearing with increased intensity in the aorta. B) Hybrid Man5GlcNAc3 (1460) N-glycoform was elevated in AS valves, Mann-Whitney U p-value <0.049. C) Example image patterns of m/z 1460 in normal valves over different pediatric ages. D) Spatial patterns of m/z 1460 in AS valve structures.