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. Author manuscript; available in PMC: 2022 May 1.
Published in final edited form as: J Mol Cell Cardiol. 2021 Jan 29;154:6–20. doi: 10.1016/j.yjmcc.2021.01.001

Figure 7. RNA-Seq measurements of sialyltransferases and sialidases.

Figure 7.

A) Overall, the human aortic valve shows active regulation of N-glycan sialic acid activity that may be dependent on the individual. B) Neuraminidases, that work on de-sialidation, and localize to different cellular compartments and cell pheontypes show negligible variation among normal or AS valves at the transcriptional level. Neu2 was not detected by RNA-Seq data. C-E) Protein expression of ST8SIA4, which is developmentally regulated in the outflow tract after post-transitional circulation shows localization to the endothelium and fibrosa valvular interstitial cells in normal functioning young valve. In the AS valve structure expression is found in endothelium and throughout the structure in valvular interstitial cells. Arrows point to endothelium expression. Star highlights internalized expression of ST8SIA4. Bar= 300 μm.