Table 1.
Glycoenzyme Category | Activity | Primary Location of Enzyme Activity |
---|---|---|
Mannosyltransferases | Transfers mannose groups onto the N-glycan precursor | E.R and golgi |
Mannosidases | Removes mannose groups off N-glycan structures | cis to medial golgi |
Fucosyltransferases | Adds fucose to the N-glycan structure | medial to trans golgi |
Fucosidases | Removes fucose from the N-glycan structure | medial to trans golgi |
N-acetylglucosaminotransferases | Increases branching of the N-glycan structure | medial to trans |
Sialyltransferase | Adds sialic acid to the N-glycan structure | trans-golgi |
Sialidases (neuraminidases) | Removes sialic acid from the structure | trans-golgi |