TABLE 3.

Univariate and Multivariable Analyses of Pre-LT Predictors of Post-LT Death Using Cox Proportional Hazards Regression Among Patients Ever Beyond Milan Criteria (n = 543)

Predictor	Hazard ratio (95% CI)	P Value
Univariate analysis
Age (per year)	0.99 (0.96–1.02)	0.59
Tumor burden at study inclusion
“AC-DS” (vs. “UNOS-DS”)	1.26 (0.77–2.04)	0.35
Number of tumors (per tumor)	1.07 (0.88–1.30)	0.51
Total tumor diameter (per cm)	1.03 (0.94–1.13)	0.53
Number of tumors plus size of largest tumor (cm)	0.99 (0.88–1.11)	0.82
Last tumor burden prior to transplant
Number of tumors (per tumor)	1.08 (0.85–1.38)	0.51
Total tumor diameter (per cm)	1.06 (0.98–1.14)	0.13
Number of tumors plus size of largest tumor (cm)	1.08 (0.996–1.17)	0.06
AFP at LT (ng/mL)
AFP > 100 (vs <20)	2.37 (1.24–4.54)	0.009
AFP 20–99 (vs. <20)	1.53 (0.91–2.55)	0.11
MELD score (per point)	0.98 (0.93–1.03)	0.39
Wait region
Mid (vs. long)	3.61 (1.64–7.96)	0.001
Short (vs. long)	2.49 (1.08–5.71)	0.03
Mid and short (vs. long)	3.12 (1.44–6.76)	0.004
Multivariable analysis
AFP > 100 ng/mL (vs. <20)	2.36 (1.24–4.52)	0.009
AFP 20–99 ng/mL (vs. <20)	1.45 (0.87–2.43)	0.15
Mid and short wait region (vs. long)	3.07 (1.41–6.67)	0.005