TABLE 3.
Univariate and Multivariate Analyses of Predictors of Post-LT Death Using Cox Proportional Hazards Regression Among Patients With HCC (n = 7563)
| Predictor | HR (95% CI) | P Value |
|---|---|---|
| Univariate analysis | ||
| Age at listing (per year) | 1.02 (1.01–1.03) | <0.001 |
| Sex, female | 0.97 (0.83–1.13) | 0.68 |
| Etiology of liver disease (reference: HCV) | ||
| NAFLD | 0.95 (0.76–1.19) | 0.64 |
| Alcohol | 1.04 (0.83–1.31) | 0.74 |
| HBV | 0.67 (0.49–0.93) | 0.02 |
| Autoimmune* | 0.95 (0.61–1.49) | 0.83 |
| Received LRT prior to transplant | ||
| Any LRT | 1.00 (0.78–1.29) | 0.99 |
| Ablation at any time | 0.91 (0.77–1.07) | 0.26 |
| TACE or Y90 at any time | 1.12 (0.98–1.29) | 0.09 |
| Last imaging prior to LT (reference: 0 lesions) | ||
| 1 lesion ≤3 cm | 1.08 (0.93–1.25) | 0.32 |
| 1 lesion 3.1–5 cm | 1.34 (1.08–1.67) | 0.009 |
| 2 lesions | 1.28 (1.06–1.56) | 0.01 |
| 3 lesions | 1.57 (1.17–2.10) | 0.002 |
| Total tumor diameter (per cm) | 1.08 (1.04–1.11) | <0.001 |
| Number of lesions plus largest lesion diameter | 1.06 (1.03–1.10) | <0.001 |
| AFP at LT (reference: <20 ng/mL) | ||
| 20 to <100 ng/mL | 1.50 (1.29–1.74) | <0.001 |
| 100 to ≤1000 ng/mL | 1.95 (1.61–2.36) | <0.001 |
| ≥1000 ng/mL | 4.04 (2.59–6.31) | <0.001 |
| RETREAT score (reference: 0) | ||
| 1 | 1.24 (1.01–1.52) | 0.04 |
| 2 | 1.83 (1.48–2.26) | <0.001 |
| 3 | 2.26 (1.80–2.85) | <0.001 |
| 4 | 2.96 (2.33–3.77) (2.326–3.77) | <0.001 |
| ≥5 | 4.50 (3.51–5.78) | <0.001 |
| MELD score (per point) | 1.01 (1.00–1.02) | 0.03 |
| Donor factors | ||
| DCD versus DBD donor | 1.32 (1.06–1.64) | 0.01 |
| Donor age (per year) | 1.01 (1.00–1.01) | 0.001 |
| DRI | 1.41 (1.21–1.65) | <0.001 |
| CIT (hours) | 0.99 (0.96–1.01) | 0.28 |
| Multivariate analysis† | ||
| Age at listing (per year) | 1.02 (1.01–1.03) | <0.001 |
| Donor age (per year) | 1.01 (1.00–1.01) | <0.001 |
| DCD versus DBD donor (versus DBD) | 1.38 (1.10–1.72) | 0.005 |
| RETREAT score (reference: 0) | ||
| 1 | 1.25 (1.02–1.53) | 0.04 |
| 2 | 1.81 (1.47–2.24) | <0.001 |
| 3 | 2.26 (1.79–2.83) | <0.001 |
| 4 | 2.92 (2.30–3.72) | <0.001 |
| ≥5 | 4.41 (3.44–5.67) | <0.001 |
| Multivariate analysis with exclusion of explant features | ||
| Age at listing (per year) | 1.02 (1.01–1.03) | <0.001 |
| Last imaging prior to LT (reference: 0 lesions) | ||
| 1 lesion ≤3 cm | 1.05 (0.91–1.22) | 0.51 |
| 1 lesion 3.1–5 cm | 1.24 (0.99–1.54) | 0.06 |
| 2 lesions | 1.19 (0.97–1.45) | 0.09 |
| 3 lesions | 1.39 (1.03–1.86) | 0.03 |
| AFP at LT (reference: <20 ng/mL) | ||
| 20 to <100 ng/mL | 1.51 (1.29–1.75) | <0.001 |
| 100 to ≤1000 ng/mL | 1.93 (1.60–2.35) | <0.001 |
| ≥1000 ng/mL | 3.99 (2.55–6.25) | <0.001 |
| MELD score ≥15 | 1.16 (1.02–1.32) | 0.02 |
| Donor age (per year) | 1.01 (1.00–1.01) | <0.001 |
| DCD versus DBD donor | 1.42 (1.13–1.77) | 0.002 |
*
Includes autoimmune hepatitis, primary biliary cholangitis, and primary sclerosing cholangitis.
†
MELD (P = 0.12) and etiology of liver disease (P = 0.49) were tested and not significantly associated with survival.