Table 5.
The most helical designed IAV entry inhibitor peptides using each of the three strategies and multiple strategies, as well as their helicity ratios
| Sequence | Helical segment | Helicity percentage (%) | |
|---|---|---|---|
| Wild peptide | LFGAIAGFIEGGWTGMIDGW | – | 0 |
| The most helical peptides obtained from each of three employed strategies | LFRAIARFIEKGWTKMIDGW | LFRAIARFIEKGWTKM | 75 |
| LFGAIAKFIEGLWTKMIDLW | FGAIAKFIEGLWTKMID | 85 | |
| LFGAIAKFIEKAWKGMIDAW | FGAIAKFIEKAWKGM | 75 | |
| LFAAIAAFIEAAWTAMIDAW | LFAAIAAFIEAAWTAMIDA | 95 | |
| Multiple strategies | LFKAIAKFIEKAWTKMIDAW | FKAIAKFIEKAWTKM | 75 |
| LFKAIAKFIEKLWTKMIDLW | FKAIAKFIEKLWTKM | 75 | |
| LFLAIAKFIELLWTKMIDLW | LAIAKFIELLWTKM | 70 | |
| LFLAIAKFIEKAWKKMIDAW | LAIAKFIEKAWKKM | 70 | |
| LFLAIAKFIEKAWKLMIDAW | LAIAKFIEKAWK | 60 | |
| LFLAIAKFIEKAWKLMIDLW | LAIAKFIEKAWK | 60 | |
| LFAAIAAFIEAAWKAMIDAW | AAIAAFIEAAWKAM | 70 | |
| LFAAIAAFIEALWKAMIDLW | AAIAAFIEALWKAM | 70 | |
| LFAKIAAFIEALWKAMIDLW | AKIAAFIEALWKAM | 70 | |
| LFKAIAKFIEKAWTKMIEAW | FKAIAKFIEKAWTKM | 75 | |
| LFKAIAKFIEKLWTKMIELW | FKAIAKFIEKLWTKMI | 80 | |
| LFLAIAKFIELLWTKMIELW | LAIAKFIELLWTKMI | 75 | |
| LFLAIAKFIEKAWKKMIEAW | LAIAKFIEKAWKKM | 70 | |
| LFAAIAAFIEAAWKAMIEAW | AAIAAFIEAAWKAM | 70 | |
| LFAAIAAFIEALWKAMIELW | AAIAAFIEALWKAMI | 75 | |
| LFAKIAAFIEALWKAMIELW | AKIAAFIEALWKAMI | 75 |
Mutated residues are underlined