Skip to main content
. Author manuscript; available in PMC: 2022 Jan 3.
Published in final edited form as: Sci Signal. 2021 Apr 20;14(679):eabc0425. doi: 10.1126/scisignal.abc0425

Figure 6. CLICs function upstream of Rac1 and RhoA in endothelial S1P signaling cascade.

Figure 6.

Both CLIC1 and CLIC4 are necessary for S1PR1-mediated endothelial behaviors and function upstream of Rac1. CLIC1, but not CLIC4, is required for S1PR2 and S1PR3 signaling and acts upstream of RhoA.