Figure 1. Sarbecovirus RBD sequence analysis.

Shown with Alpha, Beta, Delta and Omicron variants (the latter repeated on the lower line to clarify the Omicron changes. Binding sites for the early pandemic potent antibodies (Dejnirattisai et al., 2021a) and the potent Beta antibodies ((Liu et al., 2021b) are depicted using iron heat colours (grey > straw > blue > glowing red > yellow > white) to indicate relative levels of antibody contact and commercial antibody contacts are depicted with the pairs of antibodies in red or blue with purple denoting interactions with the same residue). Totally conserved residues are boxed on a red background on the upper rows, whilst on the final row the Omicron mutations are boxed in red. Secondary elements are denoted above the alignment. The figure was produced in part using Espript (Robert and Gouet, 2014).