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. 2021 Dec 20;9:794754. doi: 10.3389/fcell.2021.794754

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Copyright © 2021 Zhou, Liu, Zhang and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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m⁶A-associated proteins in HIV-infected T lymphocytes regulate the expression of HIV mRNA. METTL3/METTL14 can install m⁶A decoration on HIV mRNA, while ALKBH5 can remove such modification. YTHDF1-3 recognize the m⁶A structure and influence the expression of HIV mRNA such as Rev and p55. With the support of Rev, HIV mRNA modified by m⁶A can export nucleus more easily, which promote the replication of HIV.