TABLE 1.
Roles of m6A Writers, Erasers, and Readers in macrophages.
| m6A regulator | Cell subtype | Target genes | Biological function |
|---|---|---|---|
| Writers | |||
| METTL3 | M1 | STAT1 | Promote polarization |
| M2 | STAT1 | Inhibit polarization | |
| M1/M2 | Cgas, Ifi16, Sting, hnRNPA2B1 | Increase the production of IFN-β Amplify the immune response to DNA virus | |
| Irakm | Promote activation | ||
| METTL14 | M1/M2 | Ebi3 | suppress CD8+ T cell dysfunction and tumor growth |
| Erasers | |||
| FTO | M1 | STAT1 | Promote polarization |
| M2 | STAT6, PPAR-γ | ||
| ALKBH5 | M1/M2 | Mavs, Traf3, Traf6 | Inhibit translation and production of IFN |
| Readers | |||
| YTHDF2 | M1/M2 | STAT1, PPAR-γ | Impede macrophage activation |
| MAP2K4, MAP4K4 | Inhibit the expression of pro-inflammatory cytokine and inflammatory response | ||
| YTHDF3 | FOX O 3 | Impede the expression of IFN-stimulated genes and immunity response to VSV | |
| IGF2BP2 | TSC1, PPAR-γ | regulate macrophage phenotypic activation and inflammatory diseases | |