TABLE 2.
m6A-associated proteins in DNA repair.
| m6A regulator | Biological function |
|---|---|
| Writers | |
| METTL3 | Modulate DNA-RNA hybrid accumulation |
| Regulate accumulation of the three-stranded R-loops | |
| Regulate the m6A modification in ultraviolet-induced DNA damage | |
| Direct the recruitment of Pol κ to the DNA damage sites | |
| METTL14 | Enhance translation of DNA repair genes |
| Suppress ultraviolet-induced skin tumorigenesis | |
| KIAA1429 | Interfere with DNA damage response in cisplatin-treated germ cell tumor |
| Erasers | |
| FTO | Regulate the m6A modification in ultraviolet-induced DNA damage |
| ALKBH5 | Regulate ROS-induced DNA damage response |
| Readers | |
| YTHDC1 | Modulate DNA-RNA hybrid accumulation |
| YTHDF2 | Regulate accumulation of the three-stranded R-loops |
| IGF2BP2 | Extend mRNA half time in ROS-induced DNA damage response |