Fig 5. Up-regulation of the tRNA^Leu-CAA and tRNA^Tyr-GTA in breast organoids that escape chemotherapy.

A. Representative image of breast cancer organoids. B. Analysis by RT-QPCR of proliferative and senescence markers of two breast tumor organoids treated or not with 2 cycles of 96 hr of Doxorubicin (All experiments were performed on two organoids coming from two patients, #1: Doxorubicin 25 ng/ml, #2: Doxorubicin 50ng/ml). C, D. Analysis of the expression of the indicated RNAs on PDOs at the end of the doxorubicin treatment (E0) and 10 days later (E10).