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. 2021 Dec 20;11:788365. doi: 10.3389/fonc.2021.788365

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Copyright © 2021 Hourani, Holden, Li, Lenzo, Hadjigol and O’Brien-Simpson

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TAMs role in supporting tumor growth. TAMs mediate immunosuppression by recruiting Treg cell and inhibiting CD8+ T cells. In addition, TAMs participate in metastatic spread, angiogenesis, and drug resistance. Created with BioRender.com.