Figure 5.

666-15 treatment inhibits renal cyst growth in the late-onset ADPKD mouse model. (A) Schematic view of experimental design in the late-onset ADPKD model. (B) Representative images of P115 kidneys from WT and ADPKD mice treated with DMSO or 666-15. (C) KW/body wt (BW) ratios in the indicated groups of mice. (D) Hematoxylin and eosin staining of kidney sections from ADPKD mice treated with DMSO or 666-15. (E) Cystic index of hematoxylin and eosin–stained kidney sections from ADPKD mice treated with DMSO or 666-15. (F) Plasma BUN levels of P115 mice from the indicated groups. Data are represented as means±SEMs, and were analyzed using the unpaired, two-sided t test in (C), (E), and (F). *P<0.05, **P<0.01, ***P<0.001.