Figure 6.

Genetic inhibition of p-CREB ameliorates ADPKD progression. (A) Schematic view of experimental design in the kidney-specific mouse model. (B) Representative images of P7 kidneys from WT and ADPKD mice with or without A-CREB expression. (C) KW/body wt (BW) ratios in the indicated groups of mice. (D) Hematoxylin and eosin staining of kidney sections from ADPKD mice with or without A-CREB expression. (E) Cystic index of hematoxylin and eosin–stained kidney sections in (D). (F) Plasma BUN levels of P7 mice from the indicated groups. Data are represented as means±SEMs, and were analyzed using the unpaired, two-sided t test in (C), (E), and (F). *P<0.05.