Figure 1.

miR-23b is dysregulated in human IgAN. Next-generation sequencing of kidney biopsy tissue showed that miR-23b was downregulated in kidneys from (A) Chinese and (B, upper panel) UK patients with IgAN, compared with healthy subjects and patients with MN and TMN. RT-qPCR studies (B, lower panel) confirmed downregulation of miR-23b in the kidneys of UK patients with IgAN (n=13) compared with MN (n=6) and TMN (n=7). Furthermore, serum miR-23b levels were significantly lower in patients with IgAN compared with (C) healthy subjects and (D) negatively correlated with serum IgA1 levels in an independent Chinese IgAN cohort. *P<0.05. Data are shown as the mean±SEM.