Skip to main content
. 2021 Oct;32(10):2561–2578. doi: 10.1681/ASN.2021010133

Figure 2.

Figure 2.

Characterization of the miR-23b−/− mouse. (A) Changes in the body weight of miR-23b−/− and WT mice over the first 3 months. (B) Quantitative analysis of miR-23b in miR-23b−/− mice (n=3) in different tissues by RT-qPCR. (C) Whole-genome sequencing confirmed deletion of the miR-23b sequence. (D) Quantitative analysis of miR-23a in miR-23b−/− mice (n=3) in different tissues by RT-qPCR indicated deletion of miR-23b did not result in cluster compensation. (E) Quantitative analysis of miR-24 and -27 in kidney, two miRs closely located (<1000 bp) to miR-23b on chromosome 13, again indicated an absence of cluster compensation in miR-23b−/− mice (n=3). *P<0.05. Data are shown as the mean±SEM.