Figure 5.

miR-23b^−/− mice develop dysregulated mucosal immunity in the gut. (A) Representative images of CD19 and IgA immunofluorescence and AID immunohistochemistry staining of the intestinal mucosa from 5-month-old WT and miR-23b^−/− mice. (B) Representative images of AID, CD19, and IgA immunofluorescence staining of the intestinal mucosal of 5-month-old WT and miR-23b^−/− mice. (C) Luciferase activity in HEK 293A cells transfected with an AID 3′-UTR reporter construct demonstrates binding of miR-23b with the 3′-UTR of each reporter. *P<0.05, **P<0.01. Data are shown as mean±SEM.