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. 2021 Sep 16;38(2):453–460. doi: 10.1093/bioinformatics/btab649

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© The Author(s) 2021. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 4. — Pyramidal cell simulation. (A) Example pyramidal cell simulated with BioDynaMo. (B) Real neuron (R67nr67b-CEL1.CNG) taken from Mellström et al. (2016) and visualized with https://neuroinformatics.nl/HBP/morphology-viewer/. (C) Large-scale simulation. The model started with 5000 initial pyramidal cell bodies and contained 9 million agents after simulating 500 iterations. The simulation execution time was 35 s on a server with 72 CPU cores. (D) Morphology comparison between simulated neurons and experimental data from Mellström et al. (2016). Error bars represent the standard deviation. (A, C) A video is available in the Supplementary Materials