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. Author manuscript; available in PMC: 2022 Apr 15.
Published in final edited form as: Cancer Res. 2021 Sep 21;81(20):5325–5335. doi: 10.1158/0008-5472.CAN-21-1545

Figure 4: Xbp1 knockout suppresses tumorigenesis in Arid1a−/−/Pik3caH1047R genetic OCCC mouse model.

Figure 4:

(A) Arid1aflox/flox/Pik3caH1047R and Arid1aflox/flox/Pik3caH1047R/Xbp1flox/flox mice were intrabursally injected with Ad-Cre to knockout Arid1a and/or Xbp1 and activate Pik3caH1047R. After 6 weeks, the mice were euthanized. Shown is an image of reproductive tracts with tumors from each labeled group. (B) Tumor weight was quantified as a surrogate for the tumor burden in the indicated groups (n = 8 mice per group). (C) Mice from the indicated groups were followed for survival by the Kaplan-Meier methods (n = 8 mice per group). P values were calculated using two-tailed Student’s t-test in B and log-rank test in C. Error bars represent mean with SD.