Table 2. Summary of cases with treatment details.

	Case 1	Case 2	Case 3	Case 4
Reason to excise nipple-areola complex	Nipple tethering	Sub-areolar lump	Involved medial margin on vertical scar therapeutic mammoplasty – adjacent to nipple	Incidental cancer on duct excision for nipple discharge
Whole tumour size (in mm)	60	50	60	17 and 6
Further axillary treatment	No further treatment arm of POSNOC trial	Axillary Radiotherapy	Nil	Nil
Specimen weight (in gm)	145	82	170 therapeutic mammoplasty 52 central excision	8.5 total duct excision 35 central excision
Specimen dimensions (ML×AP×SI) mm	86×75×40	77×25×65	80×70×45 40×35×62	45×30×15 55×40×43
Surgical margins	Clear	Inferior margin focally involved with DCIS: re-excised – no further malignancy	NA (No further malignancy seen on central excision)	Clear
Closest peripheral margin	1 mm (superior)	> 5 mm	>5 mm (medial)	10 mm
Duration of surgery (in min)	140	110	120	110
Adjuvant chemotherapy	Yes	No. Oncotype RS 11 (NHS PREDICT 4% for third generation)	Yes, following vertical scar therapeutic mammoplasty	No
Adjuvant radiotherapy	Yes (breast with boost) – POSNOC no axillary RT	Yes (breast, axilla, SCF)	Yes (breast with boost)	Yes (breast)
Adjuvant endocrine therapy	Yes (Anastrozole)	Yes (Anastrozole)	Yes (Tamoxifen). Declined Zoladex, aromatase inhibitor and bisphosphonate	Yes (Tamoxifen)
Wound complication	Nil	Nil	Nil	Nil
Shoulder function recovery	Complete	Complete	Complete	Complete
Aesthetic outcome	Very good	Excellent	Excellent (right bigger than left pre radiotherapy)	Excellent

ML, medio-lateral; AP: antero-posterior; SI, supero-inferior; NA: not applicable; RS, recurrence score; RT, radiotherapy