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. 2022 Jan 4;159:110754. doi: 10.1016/j.mehy.2021.110754

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Fig. 2 — Flow chart of the one-step screening platform for high-efficient and minimal off-target CRISPR/Cas13 crRNAs targeting SARS-COV-2. Virus crRNA level indicates that the single cell is infected by a certain crRNA. Virus RdRp level indicates the knockdown efficiency induced by the crRNA in a single cell. Host transcriptome change indicates off-target effects induced by the crRNA in a single cell.