FIG. 2.

Schematic representation of the position of the exo1-dependent and pms1-A130V-dependent mutator mutations. The relative positions of the exo1-dependent (A) and pms1-A130V-dependent (B) mutator mutations on the indicated genes are indicated by the arrows. The black vertical bars in PMS1 and MLH1 indicate the position of motifs important for ATP binding. The stippled boxes in PMS1 and MLH1 indicate the position of motifs important for PMS1-MLH1 interactions. The two open vertical boxes in MSH2, MSH3, and MSH6 indicate motifs important for ATP hydrolysis. The single vertical black bars in MSH3, MSH6, and POL32 indicate the motif that is important for interaction with PCNA. The two stippled boxes in EXO1 indicate motifs thought to be important for exonuclease activity.