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. 2021 Sep 10;41(1):15–25. doi: 10.1038/s41388-021-02006-x

Fig. 1. LncRNA SAMMSON is consistently expressed in UM tumors.

Fig. 1

A RNA sequencing data from >10,000 tumor samples and 32 cancer types (TCGA) showing SAMMSON expression in skin melanoma (SKCM), uveal melanoma (UM) and other cancer types (p < 10−15, Mann–Whitney test). B RNA sequencing data showing elevated SAMMSON expression levels in metastatic UM tumors compared to matching primary tumors (n = 21, p = 0.022, Wilcoxon matched-pairs signed rank test). C Relative SAMMSON expression in CM cell lines (CRMM1, CRMM2) and UM cell lines (OMM1, OMM2.3, 92.1 and MEL270) compared to skin melanoma cell line SK-MEL28. Error bars represent ± standard error (SE) of qPCR replicates. D Relative SAMMSON expression in UM PDX lines. Error bars represent ± standard error (SE) of qPCR replicates. E Frequent chromosomal aberrations in UM tumors and the location of SAMMSON on chromosome 3, which is frequently lost. F Significantly lower ROBO1 expression levels in monosomy 3 (1 N, n = 36) tumors compared to disomy 3 (2 N, n = 44) tumors (p < 10−9, Mann–Whitney test). G No difference in SAMMSON expression levels between disomy 3 (2 N, n = 44) and monosomy 3 (1 N, n = 36) tumors (p = 0.20, Mann–Whitney test).