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. 2021 Dec 21;12:754141. doi: 10.3389/fimmu.2021.754141

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Copyright © 2021 Yang, Chen, Zheng, Li and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Components of the tripartite BBB. Glycocalyx is located on the endothelial surface of blood vessels and is in contact with various components in the blood. It is the first line of defense of BBB.