TABLE 2.

Targeted therapy of AD via CRISPR/Cas9 system.

Target genes	Main results	Model system	Delivery system	References
Amyloid precursor protein (APP)	APP↓ Aβ↓	Tg2576 mice as mutant models of APP familiar form of Alzheimer	Adeno-associated viral (AAV)-1 vectors	Gyorgy et al., 2018
3′-UTR APP	APP↓ Aβ↓	C57BL/6 mice	px330 plasmid	Nagata et al., 2018
beta-secretase 1 (Bace1)	Bace1↓ Aβ↓ Memory impairment↓	5XFAD as Alzheimer mouse model and wild-type mice	Micelle	Park et al., 2019
γ-Secretase activating protein (GSAP)	GSAP↓ γ-Secretase activity↓ Aβ↓	HEK-APP cell lines	Plasmid	Wong et al., 2019
APOE	Turning APOE4 to APOE3↑ Hyper-phosphorylation Tau protein↓ Deposition of amyloid ↓	Induced pluripotent stem cells (iPSCs)	Electroporation with three episomal plasmids	Wadhwani et al., 2019
CD33	hCD33m+ hCD33M- Aβ1–42 phagocytosis in microglia↑	U937 cells	Not mentioned	Bhattacherjee et al., 2021
Glia maturation factor (GMF)	GMF↓ p38 MAPK ↓	BV2 microglial cell line	AAVpro	Raikwar et al., 2019
CysLT1R	CysLT1R–/– hippocampal synaptic plasticity↑ amyloidogenesis↓ neuroinflammation in the hippocampus↓	APP/PS1 mice	Not mentioned	Chen et al., 2021