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. 2021 Dec 21;8:805029. doi: 10.3389/fmed.2021.805029

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Copyright © 2021 Han, Huang, Ji, Zhou, Chen and Hou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Fecal metabolic profiles in the N2 group and CON group. (A) PLS-DA of the two groups in ESI+ mode. (B) PLS-DA of the two groups in ESI– mode. (C) Classification of significantly altered metabolic features. (D) Enriched pathways of altered metabolic features using the KEGG database; Red represents “Organismal Systems;” Yellow represents “Metabolism;” green represents “Genetic Information Processing;” blue represents “Human Diseases;” Orange represents “Environmental Information Processing;” purple represents “Cellular Processes.” ESI, electrospray ionization.