Table 2.
Subgroup analyses of OS and CSS.
| Outcome | Variable | No. of studies | Model | HR (95% CI) | p | Heterogeneity | Pm | |
|---|---|---|---|---|---|---|---|---|
| I2 (%) | p | |||||||
| OS | All | 10 | Random | 1.41 (1.25, 1.59) | < 0.001 | 34.6 | 0.131 | |
| Ethnicity | Asian Caucasian |
6 4 |
Random Random | 1.49 (1.25, 1.77) 1.34 (1.11, 1.62) |
< 0.001 0.002 |
20.5 53.4 |
0.279 0.092 |
0.409 |
| Disease stage | Metastatic Non-metastatic |
5 5 |
Random Random | 1.37 (1.21, 1.54) 1.45 (1.13, 1.86) |
< 0.001 0.004 |
0.0 58.9 |
0.414 0.045 |
0.935 |
| Treatment method | Surgery Non-surgery |
7 3 |
Random Random |
1.43 (1.18, 1.72) 1.41 (1.25, 1.65) |
< 0.001 < 0.001 |
51.3 0.0 |
0.055 0.521 |
0.897 |
| Cutoff value | >1.2 ≤1.2 |
5 5 |
Random Random | 1.44 (1.18, 1.76) 1.39 (1.17, 1.65) |
<0.001 <0.001 |
51.1 27.0 |
0.085 0.242 |
0.877 |
| Analysis method | Multivariate Univariate |
6 4 |
Random Random | 1.50 (1.29, 1.73) 1.28 (1.04, 1.58) |
<0.001 0.020 |
21.7 40.8 |
0.271 0.167 |
0.220 |
| Sample size | >300 ≤300 |
5 5 |
Random Random | 1.45 (1.23, 1.71) 1.38 (1.12, 1.71) |
<0.001 0.003 |
34.1 43.3 |
0.194 0.132 |
0.629 |
| CSS | All | 7 | Random | 1.59 (1.28, 1.97) | <0.001 | 49.7 | 0.063 | |
| Ethnicity | Asian Caucasian |
5 2 |
Random Random | 1.80 (1.38, 2.33) 1.27 (1.06, 1.51) |
<0.001 0.009 |
35.6 0.0 |
0.184 0.887 |
0.086 |
| Disease stage | Metastatic Non-metastatic |
3 4 |
Random Random |
1.54 (1.14, 2.08) 1.66 (1.15, 2.40) |
<0.001 <0.001 |
60.1 50.7 |
0.082 0.107 |
0.809 |
| Cutoff value | >1.2 ≤1.2 |
4 3 |
Random Random |
1.94 (1.43, 2.64) 1.45 (1.15, 1.83) |
<0.001 0.001 |
27.3 0.0 |
0.248 0.063 |
0.067 |
| Analysis method | Multivariate Univariate |
5 2 |
Random Random |
1.76 (1.32, 2.35) 1.25 (0.90, 1.75) |
<0.001 0.184 |
63.5 0.0 |
0.027 0.816 |
0.278 |
| Sample size | >300 ≤300 |
4 3 |
Random Random | 1.42 (1.28, 1.73) 1.97 (1.25, 3.10) |
0.001 0.004 |
29.8 51.4 |
0.233 0.128 |
0.250 |
OS, overall survival; CSS, cancer-specific survival; HR, hazard ratio; CI, confidence interval.