Table 3.

Diagnostic accuracy of post-neoadjuvant vacuum-assisted biopsy considering updated exclusion criteria and updated criteria for uncertain representative biopsies

	Positive index test: assumed residual tumor	Negative index test: no residual tumor assumed
Residual disease in surgical specimen (n = 104)	101	3
No residual disease in surgical specimen (n = 131)	85	46
FNR (95 % CI), no.	2.9 % (0.1–8.2), 3 of 104
Sensitivity (95 % CI), no.	97.1 % (91.8–99.4), 101 of 104
Specificity (95 % CI), no.	35.1 % (27.0–44.0), 46 of 131
PPV (95 % CI), no.	54.3 % (46.9–61.6), 101 of 186
NPV (95 % CI), no.	93.9 % (83.1–98.7), 46 of 49

FNR false-negative rate, CI confidence interval, PPV positive predictive value, NPV negative predictive value