Fig. 1.

Analysis of published studies using iPSC technology for modeling of IEMs A Number of publications related to each of the fifteen main IEM groups as classified by the Society for the Study of Inborn Errors of Metabolism (SSIEM; classification

available at www.ssiem.org/images/centralstore/resources/SSIEMClassificationIEM2011.pdf). B Distribution of the 291 publications reviewed for the current study, indicating those that reported recapitulation of phenotypic features of IEMs, screening of novel compounds, and the combination of iPSC technology with gene editing techniques