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. 2021 Jul 9;22(4):1189–1200. doi: 10.1007/s11154-021-09671-z

Fig. 3.

Fig. 3

Comparison of different cell culture systems for modeling of IEMs. Patient-specific fibroblasts, along with their reprogrammed hiPSC and hiPSC-derivatives (in form of 2D cell cultures or organoid systems), are compared for their relative limitations and benefits. Score marks are represented as follows: ‘ + ’: not suitable; ‘ + + ’: good and ‘ + + + ’: optimal