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. 2022 Jan 4;20:6. doi: 10.1186/s12951-021-01188-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — AuNP counts versus spectral contrast γ distributions of SP_20%@AuNPs conjugated with different concentrations of a mAb_SP and b anti-BSA in TE buffer. c Digital readout signals ΔN/N0 in response to mAb_SP and anti-BSA. The red lines indicate the readout signal of LOD. d AuNP counts versus spectral contrast γ distributions of SP_20%@AuNPs conjugated with different concentrations of mAb_SP in artificial saliva (without any additive proteins, blank) and saliva buffer (S.B.) that contains HSA, IgA, IgG, and IgM. e The statistic ΔN/N0 in response to the mAb_SP. The sample of each condition was six, and the error bar is represented by ± SD. *p = 0.015< 0.05