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Illustration of the actin-associated signalling in chondrogenesis. (a) Influence of hypoxia, substrate stiffness and ras homologue family member A (RhoA)/RhoA-associated protein kinase (ROCK) signalling on chondrogenesis. Details are given in the main text. (b) Chondrogenic signalling cascade associated with hypoxia. Details are given in the main text. HIF-1α, Hypoxia-inducible factor 1α; Sox9, SRY-box transcription factor 9.
