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. 2021 Jul 22;43(1):177–193. doi: 10.1038/s41401-021-00715-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Sixty-four BALB/c nude mice were inoculated subcutaneously with MDA-MB-231 cells and randomly divided into four groups (16 mice per group, 10 mice were used for determination of survival and 6 mice for determination of tumor volume and H&E, TUNEL, and immunohistochemistry analyses). a Comparison of the overall survival of mice between vehicle, cepharanthine, epirubicin and combination of cepharanthine/epirubicin (n = 10 mice per group). Statistical significance in survival was determined by log-rank test. ***P < 0.01, comparison between epirubicin and cepharanthine/epirubicin. b, c Tumor volumes were measured on the indicated days. Data represented as mean ± SD (n = 6, **P < 0.01, ***P < 0.001, ns not significant, Student’s two-tailed unpaired t-tests). d Body weight of mice was measured on the indicated days. e Representative images of H&E, TUNEL, and immunohistochemistry staining for determination of morphology, apoptosis and expression of C-caspase 3 in xenograft tumor sections. Scar bar, 50 µm.