Skip to main content
. 2021 Mar 29;43(1):146–156. doi: 10.1038/s41401-021-00633-4

Fig. 4. Mif is a PXR agonist.

Fig. 4

a The hepatic Pxr mRNA levels of the vehicle or Mif group. b The hepatic Cyp3a11, Cyp2b10 and Ugt1a1 mRNA levels of the vehicle or Mif group. c The hepatic protein expression levels of PXR downstream targets of the vehicle or Mif group. d Quantification of CYP3A11, CYP2B10 and UGT1A1 protein levels normalized to the expression of β-ACTIN. e Dual-luciferase reporter gene assay was used to determine the effect of RIF or different concentrations of Mif on hPXR activation in HEK293T cells. The data are expressed as mean ± S.D. *P < 0.05, **P < 0.01, ***P < 0.001 and ****P < 0.0001 compared with the vehicle group (n = 3–5).