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. 2021 Jul 12;43(1):96–110. doi: 10.1038/s41401-021-00721-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Profiling of the predicted protein targets of wogonin using Discovery Studio 2017 software. b Molecular docking of wogonin binding to Bcl-2 crystal structure. c Immunohistochemistry analysis of Bcl-2 in human kidney. Scale bar = 50 μm. Data represent the mean ± SEM for 6 humans. d CETSA analysis in MPC5 cells. e Immunoprecipitation assay. Results represent mean ± SEM of three independent experiments. ***P < 0.001 vs NC. HG high glucose, NC normal control, Wog wogonin