Fig. 2. Triptolide alleviated cognitive impairment induced by chronic cerebral hypoperfusion.

Cognitive behavior was evaluated by the discrimination index in the object recognition test (a, b) and by the Morris water maze test (c–f) from 21 d to 27 d after rUCCAO in mice administered with triptolide at doses of 5 μg·kg⁻¹·d⁻¹ (TP5) or 20 μg·kg⁻¹·d⁻¹ (TP20). c Latency to reach the platform during the acquisition trials. d Searching time in the target quadrant in the probe trial. e Diagram of swimming paths in the probe trial. f Average speed in the probe trial. n = 10–12 mice per group from at least three independent behavior experiments. ***P < 0.001 vs. the sham group; ^##P < 0.01, ^###P < 0.001 vs. the rUCCAO + saline group.