Skip to main content
. 2021 Sep 3;43(1):76–85. doi: 10.1038/s41401-021-00764-8

Fig. 6. 7w and 7x inhibited LPS-induced lung inflammation in mice by targeting MD2.

Fig. 6

C57BL/6 mice were pretreated with 10 mg/kg 7w or 7x via oral administration for 7 days, followed by intracheal injection of 5 mg/kg LPS, and lung samples were obtained 6 h later. a, c TNF-α and b, d IL-6 in BALF and serum from the experimental mice were determined with ELISA. e–h The mRNA levels of inflammatory cytokines in the lung tissues were determined by RT-qPCR after LPS treatment. Cytokine gene expression was normalized to β-actin. i 7w and 7x inhibited the formation of MD2-TLR4 complex in the lung tissues. j Densitometric quantification of blot in i. Data were reported as mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001 compared with LPS group; n ≥ 6.