Fig. 7. Compounds 7w and 7x showed therapeutic effects in mice with LPS-induced ALI.
C57BL/6 mice were intragastricly administered 10 mg/kg 7w or 7x 1 h after intratracheal injection of 5 mg/kg LPS. Lung tissues and BALF were collected 6 h after LPS injection. a Representative H&E staining images of the lung. b Lung injury score as assessed by histological analysis of lung tissues. c The lung wet/dry weight ratio. d Total cells in BALF. The levels of IL-6 (e) and TNF-α (f) in BALF from the experimental mice were determined with ELISA. Data are reported as mean ± SEM, n ≥ 6 per group. *P < 0.05, **P < 0.01, ***P < 0.001 compared with LPS group.