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Pooled CRISPR-Cas9 screens can identify functional RBPs in tumor progression. (A) Schematic of in vitro genetic screening with genome-wide lentiviral sgRNA libraries (Reprint from Koike-Yusa et al. [93]). (B) Schematic of in vivo genetic screening with genome-wide lentiviral sgRNA libraries to assess sgRNA representation (Reprint from Bieging-Rolett et al. [96]).
