Table 2:
RBPs and their significance in LC progression
| RBPs | Clinical specimens | Expression level | Assay method | Correlation with histopathological features | References |
|---|---|---|---|---|---|
| HuR | 81 NSCLC tissues and 15 benign lung tissue | Upregulated | IHC | Cytoplasmic HuR correlated with VEGFC-C levels, tumor grade, differentiation status and lymph node metastasis | [59] |
| 236 NSCLC tissues | Upregulated | IHC | Cytoplasmic HuR levels correlated with tumor progression and higher microvessel density, Positive correlation of cytoplasmic and nuclear HuR levels with COX2 | [67] | |
| RBM 5 | 120 tumor and non-tumor NSCLC tissues | Downregulated | RT-PCR and WB | RBM5 protein expression correlated with smoking status, tumor stage and lymph node metastasis of NSCLC | [284] |
| RBM 47 | 175 pairs of NSCLC and adjacent non-cancerous tissues | Upregulated | IHC | RBM47 expression was associated with the pathological type | [285] |
| KHSRP | 75 pairs of cancerous and noncancerous fresh tissues from NSCLC patients | Upregulated | IHC | High expression of KHSRP associated with an advanced TNM stage and metastasis | [286] |
| hnRNP C | 75 pairs of cancerous and noncancerous fresh tissues from NSCLC patients | Upregulated | IHC | No correlation available | [286] |
| IGF2BP1 | Paired samples of NSCLC tissues and adjacent normal tissues | Upregulated | IHC | Upregulation of IGF2BP1 contributed to poorer overall survival in NSCLC | [287] |
| IGF2BP3 | Paired samples of NSCLC tissues and adjacent normal tissues | Upregulated | IHC | Upregulation of IGF2BP3 contributed to poorer overall survival in NSCLC | [287] |
| LARP1 | 84 pairs of primary NSCLC and adjacent non-tumor tissues | Upregulated | qRT-PCR | High LARP1 expression contributes to poorer survival in NSCLC | [288] |
| ESRP1 | 65 cases NSCLC, 20 cases pre-cancerous lesions, 30 benign lung nodules | Upregulated | IHC | Levels of ESRP1 independent prognostic factor for NSCLC | [289] |
| Lin 28 | 69 NSCLC tissue samples | Upregulated | RT-PCR | High levels of Lin-28 correlates with resistance to therapy | [290] |
| SRSF1 | 6 pairs of NSCLC samples and adjacent normal lung tissues | Upregulated | WB | No correlation available | [291] |
| SRSF6 | 5 normal lung and 6 lung tumor tissues | Upregulated | qRT-PCR | No correlation available | [292] |
| hnRNP A1, A2 | 16 tumor tissues from NSCLC patients and normal tissues | Upregulated | IHC, qRT-PCR | High hnRNP A1, A2 levels in combination with low-Tid-1L levels was associated with poor survival of NSCLC patients | [293] |
| PDCD4 | 28 tumor tissues from NSCLC patients and control tissues | Downregulated | qRT-PCR | No correlation available | [294] |
| QKI | 10 adenocarcinoma tissues | Downregulated | WB | No correlation available | [295] |
| MSI-2 | 123 human NSCLC tumor samples and normal lung tissues | Upregulated | TMA | High expression of MSI-2 correlated with extent of disease progression | [296] |
| 40 NSCLC patients and control tissues | Upregulated | IHC | MSI-2 correlated with decreased progression free survival and overall survival | [297] | |
| MSI-1 | 202 TMA specimens | Upregulated | TMA | No correlation available | [298] |
| Kin17 | 97 NSCLC and benign lung lesion tissue specimens | Upregulated | IHC, WB | Kin17 overexpression was associated with tumor grade and lymph node metastasis | [299] |
| eIF4E | 70 cases NSCLC, 19 NSCLC adjacent tissues and 20 normal tissues | Upregulated | TMA, IHC | Higher expression of eIF4E correlates with lymph node metastasis | [300] |
| FXR1 | 292 lung cancer tissues | Upregulated | IHC | Increased expression of FXR1 associated with poor survival of NSCLC | [301] |
| SAM 68 | 208 NSCLC samples | Upregulated | IHC | Increased expression of SAM68 correlates with lymph node metastasis and TNM stage | [302] |
| hnRNP K | 70 lung tissue samples | Upregulated | IHC | No correlation available | [303] |