Table 1:
Demographic characteristics (including admission laboratory values) and outcomes, univariate pairwise analysis
| Demographic variable |
Died (n=28) |
Survived with neurologic sequelae (n=23) |
Survived without neurologic sequelae (n=143) |
P-value comparing those who died vs. survivors |
P-value survival with vs. without sequelae |
|
|---|---|---|---|---|---|---|
| Age (months): median (IQR) | 36 (24.5 – 49.5) | 36 (18 – 74) | 55 (36 – 78) | 0.0067* | 0.04* | |
| Blantyre coma score: count (%) | ||||||
| 0 | 7 (25%) | 5 (21.7%) | 7 (4.9%) | 0.001* | <0.001* | |
| 1 | 15 (53.6%) | 8 (34.8%) | 62 (42.0%) | |||
| 2 | 6 (21.4%) | 10 (43.5%) | 76 (53.1%) | |||
| Glucose (mg/dL): median (IQR) | 86.4 (45.0 – 117.0) | 104.4 (66.6 – 138.6) | 104.4 (84.6 – 129.6) | 0.015* | 1.0 | |
| Platelets (x103)/ml: median (IQR) | 48 (9.3 – 85.9) | 43.4 (7.6 - 304) | 1.7 (0.3 – 49.8) | 0.089 | 0.084 | |
| Hematocrit (%):median (IQR) | 26.1 (21 – 30.1) | 20.5 (14.9 – 24) | 23.4 (18.9 – 27) | 0.057 | 0.048* | |
| Time from onset of fever to hospital admission (hours): median (IQR) | 48 (14 – 72) | 48 (24 -72) | 72 (48 – 72) | 0.13 | 0.50 | |
| Time from onset of coma to hospital admission (hours): median (IQR) | 10 (7 – 18) | 24 (21 -48) | 12 (7-24) | 0.26 | 0.0006* | |
| Time from last clinical convulsion until hospital admission (hours): median (IQR) | 10 (5 – 24) | 7 (0 – 24) | 5 (0 - 15.5) | 0.09 | 0.33 | |
| History of pre-hospital administration of benzodiazepines or barbiturates (%) | 17 (60.7%) | 12 (52.2%) | 75 (53.2%) | 0.45 | 0.93 | |
| Brain volume score | ||||||
| 1-6 | 12 (44.4%) | 20 (87%) | 114 (80.3%) | <0.001* | 0.45 | |
| 7-8 | 15 (55.6%) | 3 (13%) | 28 (19.7%) | |||
Variables expressed as median (IQR) for continuous variables, counts (percent) for categorical variables. P-values using ANOVA or Wilcoxon -Mann-Whitney test for continuous variables, chi square for categorical; SD = standard deviation.