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. 2021 Dec 21;9:751785. doi: 10.3389/fcell.2021.751785

FIGURE 1.

FIGURE 1

Angiogenesis is upregulated in rosacea skin samples. (A) GSEA plots of angiogenesis from RNA-Seq data in rosacea lesions and healthy skin (HS). The plots are displayed with normalized enrichment score (NES) and false discovery rate (FDR). (B,C) Immunohistochemical staining of CD31 and quantitative analysis of CD31-positive vessels on skin sections from healthy skin and rosacea lesions. Scale bar: 50 μ0. (D) mRNA expression of VEGFA and VEGFB in skin tissues from healthy skin and rosacea lesions detected by RT–qPCR. (E) GSEA plots of angiogenesis from RNA-Seq data in skin tissues from LL37-induced rosacea mouse model and control mouse. (F) Vegf mRNA expression in skin samples from LL37-induced rosacea-like mouse model and control mouse by RT-qPCR. Data represent mean ± SEM from three independent experiments. Statistical significance was determined by two-tailed unpaired Student’s t-test (C,D,F). NS, not significant. *p < 0.05 and ***p < 0.001.