Figure 4.

Mast cells and M2 macrophages are less abundant in early-onset preeclampsia (eoPE) placentas. Cell type scores were calculated based on the gene expression of CD163, MRC1, C1QA and C1QB for M2 macrophages (A), CD86 and MSR1 for M1 macrophages (B), TPSAB1 for mast cells (C). The lines represent median and interquartile ranges. Statistical significance was determined using the Kruskal-Wallis test followed by Tukey’s multiple comparisons tests. eoPE, early-onset preeclampsia; loPE, late-onset preeclampsia.