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. Author manuscript; available in PMC: 2023 Feb 1.
Published in final edited form as: Environ Toxicol. 2021 Oct 30;37(2):245–255. doi: 10.1002/tox.23394

Figure 5: Atherosclerotic lesion formation in vinyl chloride-exposed mice.

Figure 5:

(A) Vinyl chloride metabolites 2-chloroacetaldehyde (CA, 5μM) and 2-chloroethanol (CE, 5μM) increase the adhesion of murine bone marrow derived macrophages to mouse aortic endothelial cells. (B-G) Eight-week-old male Ldlr-KO mice were maintained on Western diet (WD) for 12 weeks, and body weights (B) were measured at indicated time points (n = 30/group). (C) Blood glucose level at euthanasia. (D) GTT in mice exposed to VC for 12 weeks. (E) The area under the curve (AUC) for GTT (n = 8/group). (F) Plasma cholesterol levels. (G) Lesions in the aortic valve (lipids were stained with Oil Red O). Values are mean ± SEM. *P < 0.05 vs air-exposed controls.