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. 2021 Dec 21;14:780352. doi: 10.3389/fnmol.2021.780352

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Copyright © 2021 Highet, Parker, Faull, Curtis and Ryan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

RNA integrity number (RIN) is decreased in Alzheimer’s disease hippocampus: RIN values from RNA extracted from disease affected and unaffected regions were compared between disease groups and neurologically normal cases, as well as across all regions of neurologically normal cases. (A) A significant decrease in RIN was observed in the AD HP. (B) No significant differences in RIN were observed in the CN or CB in HD. (C) No significant differences in RIN were observed in the SN or CB in PD. (D) RIN did not differ by region in normal cases. *p < 0.05.