Jiang 2017.

Methods	Study design: Randomised clinical trial Study duration: June 2012 to June 2014 Duration of follow‐up: 2 weeks Setting: Hospital
Participants	All patients were confirmed with hepatic cell carcinoma through biopsy pathology, except for patients who could not receive surgical resection of liver cancer. Age (mean ± SD, range): TACE + RFA: 63 ± 7 years, 53‐76 years; TACE alone: 63 ± 6 years, 53‐74 years Male (n/total): TACE + RFA: 30/53; TACE alone: 31/53 Child‐Pugh Class (patients): Class A: TACE + RFA: 29; TACE: 28 Class B: TACE + RFA: 21; TACE: 20 Class C: TACE + RFA: 3; TACE: 5
Interventions	TACE + RFA group (n = 53): The same TACE method was performed as that in control group. After completion, RFA was conducted, the patient’s posture was set according to the puncture path under CT guidance, CT scan locating was performed, and a 15 G RFA needle and RITA 1500 RF emitting device was used to treat the liver cancer lesions of patients. Lesion ablation temperature was set to 105 ◦C, the diameter of the ablation range might reach 5 cm, and single point puncture and ablation range superposition in different directions were adopted. TACE group (n = 53): After ensuring that the catheter was in position, 40–80 mg of cisplatin and 30–50 mg of epirubicin was injected. Then, the emulsion of 20 mg of pirarubicin + 5–20 mL of iodised oil mixture was injected.
Outcomes	Clinical efficacy assessment: measured at one and two weeks after treatment Tumour activity‐related indicators: measured at two weeks after treatment Tumour recurrence‐related indicators: measured at two weeks after treatment Serum indicators for inflammation and oxidative stress
Notes	Country of study: China Source of funding: National Natural Science Foundation of China (No.30670612); China International Medical Foundation (No.Z‐2014‐06‐15322); Navy Logistics Department (No.HJHQ‐20130987) There was insufficient information available to satisfactorily determine the method of randomisation and the study data could not be verified. We have attempted to contact the study authors for more information, but so far, we have not been successful in doing this.